U2-S02. Hapten design and synthesis

Hapten design and synthesis

Haptens are small molecules capable of eliciting an immune response when conjugated to a carrier protein. They serve as antigens for antibody production. The service designs and produces tailored haptens to match the target analyte, ensuring the desired features of the resulting antibody.

This process includes:

• Selecting the most suitable position on a drug molecule to attach a linker, maximizing specificity, sensitivity, and immunogenicity of the immunogen
• Performing total synthesis to create the hapten with a linker when the parent drug molecule lacks a functional group suitable for conjugation synthesis.
• Designing and synthesizing the linker with the optimal length.

Customer benefits

Some specific advantages that customers gain by utilizing this service include:

• Adaptation of haptens to meet specific customer needs.
• Production of highly specific and  antibodies.
• Added value in research and development by obtaining personalized immunological tools.
• Essential for organizations involved in drug discovery, diagnostics, and therapy.

Target customer

Target customer Researchers, scientists, and professionals involved in research and development in various fields including food safety and environmental control, biomedicine, diagnostics, drug discovery, and therapeutic development.

Additional information

Selected references:

• E. Montagut, J. Raya, M.-T. Martín Gómez, L. Vilaplana, B. Rodríguez-Urretavizcaya, M.-P. Marco. An Immunochemical Approach to detect the Quorum Sensing-Regulated Virulence Factor 2-Heptyl-4-Quinoline N-Oxide (HQNO) produced by Pseudomonas aeruginosa Clinical Isolates. Microbiol. Spect., 10(4), 1-12, 2022.
• B. Rodriguez-Urretavizcaya, N. Pascual, C. Pastells, M. T. Martin-Gomez, Ll. Vilaplana, M.-P. Marco. Diagnostic and Stratification of Pseudomonas aeruginosa Infected Patients by Immunochemical Quantitative Determination of Pyocyanin from Clinical Bacterial Isolates. Frontiers in Cell. Infect. Microbiol., 11, 786929, 2021. DOI: 10.3389/fcimb.2021.786929.
• J. Marrugo-Ramírez, M. Rodríguez-Núñez, M.-P Marco, M. Mir, J. Samitier. Kynurenic Acid Electrochemical Immunosensor: Blood-Based Diagnosis of Alzheimer’s Disease. Biosensors, 11(1), 20, 2021.
• E. J. Montagut, Ll. Vilaplana, M.T. Martin-Gómez, M.-P. Marco. A High Throughput Immunochemical Method to Assess 2-Heptyl-4-Quinolone Quorum Sensing Molecule as Potential Biomarker. ACS Infect. Dis., 6(12), 3237-3246, 2020.
• M. Broto, R. McCabe, R. Galve, M.-P. Marco. A high-specificity immunoassay for the therapeutic drug monitoring of ciclophosphamide. Analyst, 144, 5172-5178, 2019.